Choi EJ, Oh HT, Lee SH, Zhang CS, Li M, Kim SY, Park S, Chang TS, Lee BH, Lin SC, Jeon SM. Metabolic stress induces a double-positive feedback loop between AMPK and SQSTM1/p62 conferring dual activation of AMPK and NFE2L2/NRF2 to synergize antioxidant defense. Autophagy 2024a;20(11):2490–2510. https://doi.org/10.1080/15548627.2024.2374692

Choi G, Ju HY, Bok J, Choi J, Shin JW, Oh H, Jeon Y, Kim J, Kim D, Moon H, Lee JE, Keum YS, Kim YM, Kim HY, Park SH, Han MR, Chung Y. NRF2 is a spatiotemporal metabolic hub essential for the polyfunctionality of Th2 cells. Proc Natl Acad Sci U S A 2024b;121(28):e2319994121. https://doi.org/10.1073/pnas.2319994121

Choi H, An S, Hyun YE, Noh M, Jeong LS. Design, synthesis and biological evaluation of truncated 1′-homologated 4′-selenonucleosides as PPARγ/δ dual modulators. Bioorganic Chemistry 2024c;154:108042. https://doi.org/https://doi.org/10.1016/j.bioorg.2024.108042

Choi H, Oh D, Kim HJ, Chambugong M, Kim MH, Lee MO, Park HG. An RORalpha agonist, ODH-08, inhibits fibrogenic activation of hepatic stellate cells via suppression of SMAD3. Life Sci 2024d;340:122443.https://doi.org/10.1016/j.lfs.2024.122443

Choi YJ, Nam YA, Hyun JY, Yu J, Mun Y, Yun SH, Lee W, Park CJ, Han BW, Lee BH. Impaired chaperone-mediated autophagy leads to abnormal SORT1 (sortilin 1) turnover and CES1-dependent triglyceride hydrolysis. Autophagy 2024e;in press:in press. https://doi.org/10.1080/15548627.2024.2435234

Choi YJ, Yang HS, Zhang Y, Lee W, Yun SH, Nam YA, Lee G, Jung BH, Chang TS, Lee K, Lee BH. Intratracheal exposure to polyhexamethylene guanidine phosphate disrupts coordinate regulation of FXR-SHP-mediated cholesterol and bile acid homeostasis in mouse liver. Ecotoxicol Environ Saf 2022;247:114213. https://doi.org/10.1016/j.ecoenv.2022.114213

Choi YJ, Yun SH, Yu J, Mun Y, Lee W, Park CJ, Han BW, Lee BH. Chaperone-mediated autophagy dysregulation during aging impairs hepatic fatty acid oxidation via accumulation of NCoR1. Mol Metab 2023;76:101784. https://doi.org/10.1016/j.molmet.2023.101784

Fujiki Y, Kashiwaba M, Sato M, Kawano J, Teraoka M, Kanemitsu S, Rai Y, Taira T, Sagara Y, Ohi Y, Jo U, Lee YW, Lee SB, Gong G, Shin YK, Kwon MJ, Sagara Y. Long-term prognostic value of the GenesWell BCT score in Asian women with hormone receptor-positive/HER2-negative early breast cancer. Breast Cancer 2023;31:31-42. https://doi.org/10.1007/s12282-023-01509-7

Gi M, Oh D, Yang S, Lee J, Jung SH, Baek JH, Ha MW, Lee G, Park HG. Enantioselective Michael addition of 3-hydroxy-2-pyridone to nitroolefins using cinchona-derived bifunctional organocatalysts. Org Biomol Chem 2024;22(34):7017-7023.https://doi.org/10.1039/d4ob01042f

Hyun YE, An S, Kim M, Park IG, Yoon S, Javaid HMA, Vu TNL, Kim G, Choi H, Lee HW, Noh M, Huh JY, Choi S, Kim HR, Jeong LS. Structure-Activity Relationships of Truncated 1′-Homologated Carbaadenosine Derivatives as New PPARgamma/delta Ligands: A Study on Sugar Puckering Affecting Binding to PPARs. J Med Chem 2023;66(7):4961-4978. https://doi.org/10.1021/acs.jmedchem.2c02071

Kim D, Kim J, Yeo H, Chung Y. Immunometabolic regulation of germinal centers and its implications for aging. Curr Opin Immunol 2024a;91:102485. https://doi.org/10.1016/j.coi.2024.102485

Kim G, Hou X, Byun WS, Kim G, Jarhad DB, Lee G, Hyun YE, Yu J, Lee CS, Qu S, Warnick E, Gao ZG, Kim JY, Ji S, Shin H, Choi JR, Jacobson KA, Lee HW, Lee SK, Jeong LS. Structure-Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A(2A)/A(3) Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity. J Med Chem 2023a;66(17):12249-12265. https://doi.org/10.1021/acs.jmedchem.3c00806

Kim G, Jarhad DB, Lee G, Kim G, Hou X, Yu J, Lee CS, Warnick E, Gao ZG, Ahn SY, Kwak D, Park K, Lee SD, Park TU, Jung SY, Lee JH, Choi JR, Kim M, Kim D, Kim B, Jacobson KA, Jeong LS. Structural Modification and Biological Evaluation of 2,8-Disubstituted Adenine and Its Nucleosides as A(2A) Adenosine Receptor Antagonists: Exploring the Roles of Ribose at Adenosine Receptors. J Med Chem 2024b;67(12):10490-10507. https://doi.org/10.1021/acs.jmedchem.4c01003

Kim J, Lee BJ, Moon S, Lee H, Lee J, Kim B-S, Jung K, Seo H, Chung Y. Strategies to Overcome Hurdles in Cancer Immunotherapy. Biomaterials Research 2024c;28:0080. https://doi.org/10.34133/bmr.0080

Kim J, Lee H, Lee JE, Choi G, Chung H, Kim D, Park MJ, Gye YS, Shin KS, Kang CY, Kwok SK, Chung Y. Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1. Proc Natl Acad Sci U S A 2023b;120(9):e2213793120. https://doi.org/10.1073/pnas.2213793120

Kim M, Choi H, Nayak A, Tripathi SK, Aswar VR, Gaikwad VB, Jacobson KA, Jeong LS. Structure-Activity Relationship of Truncated 4′-Selenonucleosides: A(3) Adenosine Receptor Activity and Binding Selectivity. ACS Med Chem Lett 2024d;15(9):1620-1626. https://doi.org/10.1021/acsmedchemlett.4c00344

Kim M, Hyun YE, Kang SY, Kim SW, Park JH, Joung M, Jeong LS. Synthesis and biological evaluation of sugar-modified truncated carbanucleosides as A(2A) and A(3) adenosine receptor ligands to explore conformational effect to the receptors. Bioorg Med Chem 2024e;115:117986. https://doi.org/10.1016/j.bmc.2024.117986

Kim M, Naik SD, Choi H, Kim SW, Park JH, Joung M, Song J, Gaikwad VB, Kim M, Jeong LS. Synthesis and Biological Evaluation of 5′-Deoxy-adenosine Derivatives as A3 Adenosine Receptor Ligands. ACS Medicinal Chemistry Letters 2024f;in press:in press. https://doi.org/10.1021/acsmedchemlett.4c00522

Kim M, Naik SD, Jarhad DB, Aswar VR, Tripathi SK, Aslam MA, Huh JY, Jeong LS. Stereochemical influence of 4′-methyl substitutions on truncated 4′-thioadenosine derivatives: Impact on A(3) adenosine receptor binding and antagonism. Bioorg Chem 2024g;153:107901. https://doi.org/10.1016/j.bioorg.2024.107901

Kim SR, Park JW, Choi YJ, Sonn SK, Oh GT, Lee BH, Chang TS. Mitochondrial H(2)O(2) Is a Central Mediator of Diclofenac-Induced Hepatocellular Injury. Antioxidants (Basel) 2023c;13(1)https://doi.org/10.3390/antiox13010017

Kim SR, Park JW, Lee BH, Lim KM, Chang TS. Peroxiredoxin V Protects against UVB-Induced Damage of Keratinocytes. Antioxidants (Basel) 2023d;12(7)https://doi.org/10.3390/antiox12071435

Koh CH, Kim BS, Kang CY, Chung Y, Seo H. IL-17 and IL-21: Their Immunobiology and Therapeutic Potentials. Immune Netw 2024;24(1):e2. https://doi.org/10.4110/in.2024.24.e2

Koh CH, Lee S, Kwak M, Kim BS, Chung Y. CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential. Exp Mol Med 2023;55(11):2287-2299. https://doi.org/10.1038/s12276-023-01105-x

Kuen D, Hong J, Lee S, Koh CH, Kwak M, Kim BS, Jung M, Kim YJ, Cho BS, Kim BS, Chung YS. A Personalized Cancer Vaccine that Induces Synergistic Innate and Adaptive Immune Responses. Advanced Materials 2023;35(36):2303080. https://doi.org/10.1002/adma.202303080

Lee J-E, Kim M, Ochiai S, Kim S-H, Yeo H, Bok J, Kim J, Park M, Kim D, Lamiable O, Lee M, Kim M-J, Kim HY, Ronchese F, Kwon SW, Lee H, Kim T-G, Chung Y. Tonic type 2 immunity is a critical tissue checkpoint controlling autoimmunity in the skin. Cell Reports 2024;43(7):114364. https://doi.org/10.1016/j.celrep.2024.114364

Lee W, Mun Y, Lee KY, Park JM, Chang TS, Choi YJ, Lee BH. Mefenamic Acid-Upregulated Nrf2/SQSTM1 Protects Hepatocytes against Oxidative Stress-Induced Cell Damage. Toxics 2023;11(9):735. https://doi.org/10.3390/toxics11090735

Mekonnen N, Seo MR, Yang H, Chelakkot C, Choi JY, Hong S, Song K, Shin YK. Design, Screening and Development of Asymmetric siRNAs Targeting the MYC Oncogene in Triple-Negative Breast Cancer. Biomol Ther (Seoul) 2025;33(1):155-169. https://doi.org/10.4062/biomolther.2024.071

Naik SD, Kim M, Choi J, Kim G, Woo Kim S, Aswar VR, Tripathi SK, Gaikwad V, Yu J, Shin Jeong L. Exploring C2 and N(6) Substituent Effects on Truncated 4′-Thioadenosine Derivatives as Dual A(2A) and A(3) Adenosine Receptor Ligands. ChemMedChem 2024;2024:e202400575. https://doi.org/10.1002/cmdc.202400575

Oh D, Lee J, Yang S, Jung SH, Kim M, Lee G, Park HG. Enantioselective Synthesis of (R)-Sitagliptin via Phase-Transfer Catalytic aza-Michael Addition. ACS Omega 2024a;9(13):15328-15338. https://doi.org/10.1021/acsomega.3c10080

Oh EB, Shin HJ, Yu H, Jang J, Park JW, Chang TS. NADPH oxidase 1/4 dual inhibitor setanaxib suppresses platelet activation and thrombus formation. Life Sci 2024b;357:123061. https://doi.org/10.1016/j.lfs.2024.123061

Park J, Chang ES, Kim JY, Chelakkot C, Sung M, Song JY, Jung K, Lee JH, Choi JY, Kim NY, Lee H, Kang MR, Kwon MJ, Shin YK, Park YH, Choi YL. c-MET-positive circulating tumor cells and cell-free DNA as independent prognostic factors in hormone receptor-positive/HER2-negative metastatic breast cancer. Breast Cancer Res 2024;26(1):13. https://doi.org/10.1186/s13058-024-01768-y

Sung K, Aswar VR, Song J, Jarhad DB, Jeong LS. Stereoselective Approach for the Synthesis of Diverse 1′-Modified Carbanucleosides. Org Lett 2023a;25(46):8377-8381.https://doi.org/10.1021/acs.orglett.3c03518

Sung K, Hyeon S, Kim M, Sahu PK, Naik SD, Aswar VR, Tripathi SK, Chang TS, Ahn JH, Yu J. Design, Synthesis, and Molecular Docking Analysis of Fluorinated MLN4924 Derivatives as Antiviral Agents. Asian Journal of Organic Chemistry 2023b;12(11):e202300416. https://doi.org/10.1002/ajoc.202300416

Sung K, Oh S, Kim H-R, Hyeon S, Ahn J-H, Kim S, Aswar VR, Tripathi SK, Yu J, Shin Jeong L. Development of 4′-Oxo-MLN4924 as potential neddylation inhibitors: Design, synthesis, anti-HCMV evaluation, and molecular docking. Results in Chemistry 2024;11:101765. https://doi.org/https://doi.org/10.1016/j.rechem.2024.101765