2026년

Kim SW, Bok J, Choi H, Kim G, Kim M, Chung Y, Jeong LS. Structure-activity relationship analysis of 5′-substituted C2-hexynyl-4′-thioadenosine analogs as dual A(2A)/A(3) adenosine receptor agonists with tunable selectivity and anti-inflammatory activity. Eur J Med Chem 2026;302(Pt 3):118386. https://doi.org/10.1016/j.ejmech.2025.118386

Wang SB, Oh EB, Kim S, Sohn J, Kim T, Chang T-S. Mechanistic insights into PPARγ’s role in suppressing collagen-driven platelet activation. Life Sciences 2026;385:124138. https://doi.org/https://doi.org/10.1016/j.lfs.2025.124138

Yum YA, Aswar VR, Gaikwad V, Tripathi SK, Jarhad DB, Jeong LS. Late-Stage Conversion of Terminal Alkynes to Nitriles in Nucleoside Scaffolds: A Tool for Diversification. Asian Journal of Organic Chemistry accepted;n/a(n/a):e70235. https://doi.org/10.1002/ajoc.70235

 

2025년

Aswar VR, Jarhad DB, Song J, Yu J, Jeong LS. Design, Synthesis and Biological Evaluation of N6-Substituted-C2-Alkynyl-4′-Thionucleoside and 4′-Trucatedthionucleoside Derivatives as Novel A(3) Adenosine Receptor Ligands. ChemMedChem 2025;20(13):e202500135. https://doi.org/10.1002/cmdc.202500135

Choi YJ, Nam YA, Hyun JY, Yu J, Mun Y, Yun SH, Lee W, Park CJ, Han BW, Lee BH. Impaired chaperone-mediated autophagy leads to abnormal SORT1 (sortilin 1) turnover and CES1-dependent triglyceride hydrolysis. Autophagy 2025;21(4):827-839. https://doi.org/10.1080/15548627.2024.2435234

Jang J, Yu H, Oh EB, Park JW, Kim S, Kim T, Sohn J, Jin BR, Chang TS. Targeting NADPH Oxidase with APX-115: Suppression of Platelet Activation and Thrombotic Response. Antioxid Redox Signal 2025a;https://doi.org/10.1089/ars.2024.0695

Jang N, Kim IK, Jung D, Chung Y, Kang YP. Regulation of Ferroptosis in Cancer and Immune Cells. Immune Netw 2025b;25(1):e6. https://doi.org/10.4110/in.2025.25.e6

Joung M, Choi H, Kim M, Kim SW, Kim G, Aswar VR, Baek S, Kim HT, Huh WK, Jeong LS. Design, Synthesis, and Biological Evaluation of C2-(N-Substituted Amino) Truncated 4′-Thioadenosine Derivatives as A(2A)AR and A(3)AR Dual Ligands. ACS Med Chem Lett 2025;16(12):2512-2519. https://doi.org/10.1021/acsmedchemlett.5c00601

Kim G, Kim SW, Choi H, Kim JY, Ahn SY, Lee JH, Lee JE, Jeon YH, Jeong LS. Regio- and Stereoselective Ribose Modification in Truncated 2,8-Disubstituted Adenosine Scaffold to Develop Highly Potent A(2A) Adenosine Receptor Antagonists. J Med Chem 2025a;https://doi.org/10.1021/acs.jmedchem.5c01774

Kim G, Lee G, Jarhad DB, Gao Z-G, Kim SW, Joung M, Jacobson KA, Jeong LS. Structure–Activity Relationship Analysis of 2-Aryl-8-alkynyl Adenine and Nucleoside Scaffolds as A3 Adenosine Receptor Ligands. ACS Med Chem Lett 2025b;https://doi.org/10.1021/acsmedchemlett.5c00138

Kim H, Kim SW, Choi C, Joo S, Kim G, Kim M, Yang E, Lee J, Chung S, Jeong LS, Lee YH. Comparative analysis of LJ-4378 and tirzepatide in mouse models of obesity and weight regain. Arch Pharm Res 2025c;48(11-12):1441-1459. https://doi.org/10.1007/s12272-025-01575-9

Kim M, Lee MK, Jo I, Jang Y, Han SB, Lee J, Yang A, Jarhad DB, Choi H, Nogi Y, Saito-Tarashima N, Minakawa N, Kim M, Jeong LS. Identification of 4′-Thiouridine as an Orally Available Antiviral Agent Targeting Both RdRp and NiRAN Functions of SARS-CoV-2 Nsp12. J Med Chem 2025d;68(12):12414-12433. https://doi.org/10.1021/acs.jmedchem.4c02874

Kim M, Naik SD, Kim SW, Joung M, Yum YA, Aswar VR, Jeong LS. Design, synthesis, and biological evaluation of 5ʹ-deoxy (N)-methanocarbanucleoside derivatives as A3 adenosine receptor ligands. Bioorganic & Medicinal Chemistry Letters 2025e;120:130134. https://doi.org/https://doi.org/10.1016/j.bmcl.2025.130134

Kim SW, Bok J, Choi H, Kim G, Kim M, Chung Y, Jeong LS. Structure-activity relationship analysis of 5′-substituted C2-hexynyl-4′-thioadenosine analogs as dual A(2A)/A(3) adenosine receptor agonists with tunable selectivity and anti-inflammatory activity. Eur J Med Chem 2026;302(Pt 3):118386. https://doi.org/10.1016/j.ejmech.2025.118386

Mekonnen N, Yang H, Rajasekaran N, Song K, Choi YL, Shin YK. Indirect targeting of MYC and direct targeting in combination with chemotherapies are more effective than direct mono-targeting in triple negative breast cancer. Transl Oncol 2025;51:102204. https://doi.org/10.1016/j.tranon.2024.102204

Mun Y, Kim J, Choi Y-J, Lee B-H. cGAS–STING–NF-κB Axis Mediates Rotenone-Induced NLRP3 Inflammasome Activation Through Mitochondrial DNA Release. Antioxidants 2025;14(11):1276. https://doi.org/10.3390/antiox14111276

Oh EB, Kong YJ, Kim T, Jang J, Yu H, Park JW, Kim S, Kim T, Sohn J, Chang T-S. NADPH oxidase 2 inhibitor GSK2795039 exerts antiplatelet and antithrombotic activity. Scientific Reports 2025;15(1):36270. https://doi.org/10.1038/s41598-025-20250-z

Park J, Chelakkot C, Nam JH, Lee HS, Kim CR, Lee Y, Lee MS, Choi YL, Shin YK. MET Alterations in Cancer and MET-Targeted Therapy: Detection Strategies, Treatment Efficacy, and Emerging Technologies. Target Oncol 2025a;20(5):767-789. https://doi.org/10.1007/s11523-025-01166-0

Park JH, Tran PT, Ko HL, Mun S, Jang SC, Moon DH, Han J, Kim J, Kim G, Choi H, Kim SW, Kim M, Lee SK, Han BW, Kang KW, Jeong LS. Design, Synthesis, and Biological Evaluation of 5′,7-Disubstituted 7-Deaza-adenosine Analogues as Irreversible Pan-FGFR Inhibitors. Pharmaceuticals (Basel) 2025b;18(11)https://doi.org/10.3390/ph18111745

Park JW, Sonn SK, Lee BH, Oh GT, Chang TS. Peroxiredoxin Ⅲ mitigates mitochondrial H(2)O(2)-mediated damage and supports quality control in cardiomyocytes under hypoxia-reoxygenation stress. Redox Biol 2025c;86:103799. https://doi.org/10.1016/j.redox.2025.103799

Song J, Aswar VR, Jarhad DB, Jeong LS. Trifluoromethylation on a Nucleoside Sugar Scaffold: Design and Synthesis of 6′-Trifluoromethylcyclopentenyl-purine and -pyrimidine Nucleosides. Org Lett 2025a;27(9):2215-2219. https://doi.org/10.1021/acs.orglett.5c00325

Song J, Choi H, Kim M, Jarhad DB, Jang Y, Lee H, Kim M, Park JW, Chang TS, Aswar VR, Jeong LS. Design, Synthesis, and Antiviral Activity of 8‑Aza Fluoroneplanocin Derivatives Targeting SAH Hydrolase and Viral RdRp. ACS Med Chem Lett 2025b;16(11):2248-2256. https://doi.org/10.1021/acsmedchemlett.5c00463

Wang SB, Oh EB, Kim S, Sohn J, Kim T, Chang T-S. Mechanistic insights into PPARγ’s role in suppressing collagen-driven platelet activation. Life Sciences 2026;385:124138. https://doi.org/10.1016/j.lfs.2025.124138

Yang S, Lee J, Kim HK, Lee G, Ha MW, Pavankumar K, Kim M-h, Park H-g. Highly Enantioselective Synthesis of γ-Carboxy-β-amino Acids via Desymmetric Alcoholysis of 3-Aminoglutaric Anhydrides. Organic Letters 2025;https://doi.org/10.1021/acs.orglett.5c00955

Yum YA, Aswar VR, Gaikwad V, Tripathi SK, Jarhad DB, Jeong LS. Late-Stage Conversion of Terminal Alkynes to Nitriles in Nucleoside Scaffolds: A Tool for Diversification. Asian Journal of Organic Chemistry accepted;n/a(n/a):e70235. https://doi.org/10.1002/ajoc.70235

Zheng R, Park JW, Oh EB, Chang T-S, Chin Y-W. Chemical Constituents from the Leaves of Eruca sativa (Rocket Salad) Exhibiting Dual Cardioprotective and Antiplatelet Activities. ACS Omega 2025;https://doi.org/10.1021/acsomega.5c05585

   

2024년

Choi EJ, Oh HT, Lee SH, Zhang CS, Li M, Kim SY, Park S, Chang TS, Lee BH, Lin SC, Jeon SM. Metabolic stress induces a double-positive feedback loop between AMPK and SQSTM1/p62 conferring dual activation of AMPK and NFE2L2/NRF2 to synergize antioxidant defense. Autophagy 2024a;20(11):2490–2510. https://doi.org/10.1080/15548627.2024.2374692

 

Choi G, Ju HY, Bok J, Choi J, Shin JW, Oh H, Jeon Y, Kim J, Kim D, Moon H, Lee JE, Keum YS, Kim YM, Kim HY, Park SH, Han MR, Chung Y. NRF2 is a spatiotemporal metabolic hub essential for the polyfunctionality of Th2 cells. Proc Natl Acad Sci U S A 2024b;121(28):e2319994121. https://doi.org/10.1073/pnas.2319994121

 

Choi H, An S, Hyun YE, Noh M, Jeong LS. Design, synthesis and biological evaluation of truncated 1′-homologated 4′-selenonucleosides as PPARγ/δ dual modulators. Bioorganic Chemistry 2024c;154:108042. https://doi.org/https://doi.org/10.1016/j.bioorg.2024.108042

 

Choi H, Oh D, Kim HJ, Chambugong M, Kim MH, Lee MO, Park HG. An RORalpha agonist, ODH-08, inhibits fibrogenic activation of hepatic stellate cells via suppression of SMAD3. Life Sci 2024d;340:122443.https://doi.org/10.1016/j.lfs.2024.122443

 

Choi YJ, Nam YA, Hyun JY, Yu J, Mun Y, Yun SH, Lee W, Park CJ, Han BW, Lee BH. Impaired chaperone-mediated autophagy leads to abnormal SORT1 (sortilin 1) turnover and CES1-dependent triglyceride hydrolysis. Autophagy 2024e;in press:in press. https://doi.org/10.1080/15548627.2024.2435234

 

Gi M, Oh D, Yang S, Lee J, Jung SH, Baek JH, Ha MW, Lee G, Park HG. Enantioselective Michael addition of 3-hydroxy-2-pyridone to nitroolefins using cinchona-derived bifunctional organocatalysts. Org Biomol Chem 2024;22(34):7017-7023.https://doi.org/10.1039/d4ob01042f

 

Kim D, Kim J, Yeo H, Chung Y. Immunometabolic regulation of germinal centers and its implications for aging. Curr Opin Immunol 2024a;91:102485. https://doi.org/10.1016/j.coi.2024.102485

 

Kim G, Jarhad DB, Lee G, Kim G, Hou X, Yu J, Lee CS, Warnick E, Gao ZG, Ahn SY, Kwak D, Park K, Lee SD, Park TU, Jung SY, Lee JH, Choi JR, Kim M, Kim D, Kim B, Jacobson KA, Jeong LS. Structural Modification and Biological Evaluation of 2,8-Disubstituted Adenine and Its Nucleosides as A(2A) Adenosine Receptor Antagonists: Exploring the Roles of Ribose at Adenosine Receptors. J Med Chem 2024b;67(12):10490-10507. https://doi.org/10.1021/acs.jmedchem.4c01003

 

Kim J, Lee BJ, Moon S, Lee H, Lee J, Kim B-S, Jung K, Seo H, Chung Y. Strategies to Overcome Hurdles in Cancer Immunotherapy. Biomaterials Research 2024c;28:0080. https://doi.org/10.34133/bmr.0080

 

Kim M, Choi H, Nayak A, Tripathi SK, Aswar VR, Gaikwad VB, Jacobson KA, Jeong LS. Structure-Activity Relationship of Truncated 4′-Selenonucleosides: A(3) Adenosine Receptor Activity and Binding Selectivity. ACS Med Chem Lett 2024d;15(9):1620-1626. https://doi.org/10.1021/acsmedchemlett.4c00344

 

Kim M, Hyun YE, Kang SY, Kim SW, Park JH, Joung M, Jeong LS. Synthesis and biological evaluation of sugar-modified truncated carbanucleosides as A(2A) and A(3) adenosine receptor ligands to explore conformational effect to the receptors. Bioorg Med Chem 2024e;115:117986. https://doi.org/10.1016/j.bmc.2024.117986

 

Kim M, Naik SD, Choi H, Kim SW, Park JH, Joung M, Song J, Gaikwad VB, Kim M, Jeong LS. Synthesis and Biological Evaluation of 5′-Deoxy-adenosine Derivatives as A3 Adenosine Receptor Ligands. ACS Medicinal Chemistry Letters 2024f;in press:in press. https://doi.org/10.1021/acsmedchemlett.4c00522

 

Kim M, Naik SD, Jarhad DB, Aswar VR, Tripathi SK, Aslam MA, Huh JY, Jeong LS. Stereochemical influence of 4′-methyl substitutions on truncated 4′-thioadenosine derivatives: Impact on A(3) adenosine receptor binding and antagonism. Bioorg Chem 2024g;153:107901. https://doi.org/10.1016/j.bioorg.2024.107901

 

Naik SD, Kim M, Choi J, Kim G, Woo Kim S, Aswar VR, Tripathi SK, Gaikwad V, Yu J, Shin Jeong L. Exploring C2 and N(6) Substituent Effects on Truncated 4′-Thioadenosine Derivatives as Dual A(2A) and A(3) Adenosine Receptor Ligands. ChemMedChem 2024;2024:e202400575. https://doi.org/10.1002/cmdc.202400575

 

Oh D, Lee J, Yang S, Jung SH, Kim M, Lee G, Park HG. Enantioselective Synthesis of (R)-Sitagliptin via Phase-Transfer Catalytic aza-Michael Addition. ACS Omega 2024a;9(13):15328-15338. https://doi.org/10.1021/acsomega.3c10080

 

Oh EB, Shin HJ, Yu H, Jang J, Park JW, Chang TS. NADPH oxidase 1/4 dual inhibitor setanaxib suppresses platelet activation and thrombus formation. Life Sci 2024b;357:123061. https://doi.org/10.1016/j.lfs.2024.123061

 

Park J, Chang ES, Kim JY, Chelakkot C, Sung M, Song JY, Jung K, Lee JH, Choi JY, Kim NY, Lee H, Kang MR, Kwon MJ, Shin YK, Park YH, Choi YL. c-MET-positive circulating tumor cells and cell-free DNA as independent prognostic factors in hormone receptor-positive/HER2-negative metastatic breast cancer. Breast Cancer Res 2024;26(1):13. https://doi.org/10.1186/s13058-024-01768-y

 

Sung K, Oh S, Kim H-R, Hyeon S, Ahn J-H, Kim S, Aswar VR, Tripathi SK, Yu J, Shin Jeong L. Development of 4′-Oxo-MLN4924 as potential neddylation inhibitors: Design, synthesis, anti-HCMV evaluation, and molecular docking. Results in Chemistry 2024;11:101765. https://doi.org/https://doi.org/10.1016/j.rechem.2024.101765

 

Koh CH, Kim BS, Kang CY, Chung Y, Seo H. IL-17 and IL-21: Their Immunobiology and Therapeutic Potentials. Immune Netw 2024;24(1):e2. https://doi.org/10.4110/in.2024.24.e2

 

Lee J-E, Kim M, Ochiai S, Kim S-H, Yeo H, Bok J, Kim J, Park M, Kim D, Lamiable O, Lee M, Kim M-J, Kim HY, Ronchese F, Kwon SW, Lee H, Kim T-G, Chung Y. Tonic type 2 immunity is a critical tissue checkpoint controlling autoimmunity in the skin. Cell Reports 2024;43(7):114364. https://doi.org/10.1016/j.celrep.2024.114364

 

 

2023년

Sung K, Aswar VR, Song J, Jarhad DB, Jeong LS. Stereoselective Approach for the Synthesis of Diverse 1′-Modified Carbanucleosides. Org Lett 2023a;25(46):8377-8381.https://doi.org/10.1021/acs.orglett.3c03518

 

Sung K, Hyeon S, Kim M, Sahu PK, Naik SD, Aswar VR, Tripathi SK, Chang TS, Ahn JH, Yu J. Design, Synthesis, and Molecular Docking Analysis of Fluorinated MLN4924 Derivatives as Antiviral Agents. Asian Journal of Organic Chemistry 2023b;12(11):e202300416. https://doi.org/10.1002/ajoc.202300416

 

Kim J, Lee H, Lee JE, Choi G, Chung H, Kim D, Park MJ, Gye YS, Shin KS, Kang CY, Kwok SK, Chung Y. Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1. Proc Natl Acad Sci U S A 2023b;120(9):e2213793120. https://doi.org/10.1073/pnas.2213793120

 

Kim SR, Park JW, Choi YJ, Sonn SK, Oh GT, Lee BH, Chang TS. Mitochondrial H(2)O(2) Is a Central Mediator of Diclofenac-Induced Hepatocellular Injury. Antioxidants (Basel) 2023c;13(1)https://doi.org/10.3390/antiox13010017

 

Kim SR, Park JW, Lee BH, Lim KM, Chang TS. Peroxiredoxin V Protects against UVB-Induced Damage of Keratinocytes. Antioxidants (Basel) 2023d;12(7)https://doi.org/10.3390/antiox12071435

 

Koh CH, Lee S, Kwak M, Kim BS, Chung Y. CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential. Exp Mol Med 2023;55(11):2287-2299. https://doi.org/10.1038/s12276-023-01105-x

 

Kuen D, Hong J, Lee S, Koh CH, Kwak M, Kim BS, Jung M, Kim YJ, Cho BS, Kim BS, Chung YS. A Personalized Cancer Vaccine that Induces Synergistic Innate and Adaptive Immune Responses. Advanced Materials 2023;35(36):2303080. https://doi.org/10.1002/adma.202303080

 

Lee W, Mun Y, Lee KY, Park JM, Chang TS, Choi YJ, Lee BH. Mefenamic Acid-Upregulated Nrf2/SQSTM1 Protects Hepatocytes against Oxidative Stress-Induced Cell Damage. Toxics 2023;11(9):735. https://doi.org/10.3390/toxics11090735

 

 

2022년

Choi YJ, Yang HS, Zhang Y, Lee W, Yun SH, Nam YA, Lee G, Jung BH, Chang TS, Lee K, Lee BH. Intratracheal exposure to polyhexamethylene guanidine phosphate disrupts coordinate regulation of FXR-SHP-mediated cholesterol and bile acid homeostasis in mouse liver. Ecotoxicol Environ Saf 2022;247:114213. https://doi.org/10.1016/j.ecoenv.2022.114213